This week: TweetDeck
TweetDeck. It allows me to read and post to both my Facebook stream and my twitter feeds. For twitter it allows for direct messages, retweets, and replies. For Facebook, it allows me to 'like' and reply messages.
I can add custom columns, as many as I please, in order to follow specific feeds separately.
I currently use the android app, the web app(using chrome), and a stand alone iOS app on my MacBook Pro
It is currently lacking Google+ integration, but I think that is a limitation of the Google+ API not TweetDeck.